2-Trifluoromethyl-nicotinic acid ethyl ester

2-Trifluoromethyl-nicotinic acid ethyl ester - Names and Identifiers

Name	Ethyl 2-(trifluoromethyl)nicotinate
Synonyms	Ethyl 2-(trifluoromethyl)nicotinate 2-Trifluoromethylnicotinic acid ethyl ester 2-Trifluoromethyl-nicotinic acid ethyl ester ethyl 2-(trifluoroMethyl)pyridine-3-carboxylate 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER
CAS	208517-35-5
EINECS	1312995-182-4

2-Trifluoromethyl-nicotinic acid ethyl ester - Physico-chemical Properties

Molecular Formula	C9H8F3NO2
Molar Mass	219.16
Density	1.284±0.06 g/cm3(Predicted)
Boling Point	235.8±40.0 °C(Predicted)
pKa	-1.38±0.22(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

2-Trifluoromethyl-nicotinic acid ethyl ester - Reference Information

overview

ethyl 3-trifluoromethylnicotinate can be used as an intermediate in pharmaceutical synthesis, which can be prepared by reacting oxalyl chloride with 1-(ethylene oxy) butane and ethyl trifluoroacetoacetate to prepare intermediate ethyl 5-(dimethylamino)-2-(2,2, 2-Trifluoroacetyl)-penta-2, 4-dienoic acid, which is further prepared by aromatization.

Last Update：2024-04-09 21:31:57